Sitagliptin Base Suppliers & Exporters in Mumbai, India

CAS Number:486460‑32‑6

Synonyms: Sitagliptin free base; (R)-7‑[(3‑Trifluoromethyl‑5,6‑dihydro[1,2,4]triazolo[4,3‑a]pyrazin‑7‑yl)amino]‑3‑(2,4,5‑trifluorophenyl)‑4‑oxo‑1‑butanamine

Chemical Formula:C₁₆H₁₅F₆N₅O

Molecular Weight:419.3 g/mol

Product Introduction

A white to off-white, non‑hygroscopic powder that serves as the API precursor for sitagliptin phosphate tablets (e.g., Januvia). Sitagliptin is an oral DPP‑4 inhibitor used to improve glycemic control in adults with type 2 diabetes

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Physical & Chemical Properties

Property	Value
Appearance	White to off‑white powder
Solubility	Soluble in methanol; slight solubility in water
Melting Point	N/A (typically characterized via powder diffraction)
pKₐ (amine)	Basic; typical secondary amine range (~9–10)
Bioavailability (phosphate salt)	~87% when dosed orally
Protein Binding	~38%
Half‑life (phosphate salt)	8–14 h
Excretion	~79% unchanged via kidneys

Applications

Pharmaceutical API base for sitagliptin-containing tablets (25, 50, 100 mg) such as Januvia
Used as a reference/clinical standard in drug manufacturing

Safety & Handling

Handle in controlled environments (e.g., GMP). Use PPE, avoid ingestion/inhalation. Store sealed in a cool, dry place. Consult pharmacopeial monograph.