Ethyl Chloro Formate

Ethyl Chloro Formate

CAS Number:541‑41‑3

Synonyms: Ethyl chloroformate; Ethyl chlorocarbonate; Chloroformic acid ethyl ester; Cathyl chloride; ECF

Chemical Formula::C₃H₅ClO₂

Product Introduction

Ethyl chloroformate is a colorless, corrosive, highly reactive liquid with a pungent odor. Used as a reagent in organic synthesis for introducing ethyl carbamate protecting groups, forming carboxylic anhydrides, and derivatizing compounds for GC analysis.

Get Quote

Physical & Chemical Properties

Property Value
Appearance Colorless liquid
Odor Sharp, pungent (like HCl)
Density @ 25 °C ~1.135 g/cm³
Melting Point –81 °C
Boiling Point ~93 °C
Flash Point (CC) ~10–16 °C
Vapor Pressure @ 20 °C ~54 hPa
Vapor Density ~3.7–3.75 × air
Refractive Index (n₂₀ᴅ) ~1.395
Solubility Reacts/decomposes in water; miscible with alcohols, ethers, benzene
Explosion Limits 3.7–12.6 %

Applications

  • Carbamate protection: Converts amines to ethyl carbamates in peptide and organic synthesis.
  • Mixed anhydride formation: Activates carboxylic acids for coupling reactions.
  • Analytical derivatization: Preps compounds (amino acids, phenols) for GC analysis.

Safety Notes

  • Highly toxic, corrosive, flammable; vapor harmful; emits HCl and CO₂ with moisture.
  • Attacks metals in humid air; handle under anhydrous conditions.

Products Category

+91 9867824846
Enquiry Now