Di Tert Butyl Dicarbonate

Di Tert Butyl Dicarbonate

CAS Number:24424‑99‑5

General Formula:C₁₀H₁₈O₅

Product Introduction

Also known as Boc anhydride, a white to light-yellow powder or low-melting solid. Boc₂O is the go-to reagent for introducing the acid-labile Boc protecting group on amines (amines → Boc carbamates) in peptide, pharmaceutical synthesis, and organic chemistry.

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Properties

Property Value
Melting Point ~22–24 °C
Boiling Point ~56–57 °C @ 0.5 mmHg
Density ~1.02 g/mL @ 20 °C
Flash Point ~37 °C
Physical Form Solid or liquid depending on temperature

Applications

  • Main reagent for N-Boc protection in peptides & amino acids
  • Used in carboxylate ester formation (Heck reaction), formation of oxazolidinones, isocyanates, and Boc-ylation under mild conditions

Safety & Handling

  • Reacts with moisture → t-butanol + CO₂,causing pressure build-up; store under inert gas and keep dry
  • Flammable and moisture-sensitive solid;avoid heat & store in fridge (0–10 °C)
  • Use PPE, fume hood; sealed inert containers recommended

Packing Options

  • Lab: 10 g–1 kg glass bottles (stone-ground lids)
  • Industrial: 25–200 kg drums; can be supplied as stabilized 30% solution in THF/toluene

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