Di Iso propyl ethyl amine

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DIPEA Chemical

CAS Number:7087‑68‑5

Synonyms:N‑Ethyl‑N‑(propan‑2‑yl)propan‑2‑amine; Ethyldi(propan‑2‑yl)amine; Hünig’s base; DIPEA; DIEA

Chemical Formula:C₈H₁₉N

Product Introduction

DIPEA is a colorless liquid tertiary amine with an ammoniacal or fishy odor. It is a sterically hindered, non‑nucleophilic base widely used in organic synthesis—especially for acylations, peptide coupling, and deprotonations.

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Physical & Chemical Properties

Property Value
Appearance Colorless liquid
Odor Fishy, ammoniacal
Density @ 20 °C 0.742 g/cm³
Melting Point –50 °C to –46 °C
Boiling Point ~399.7 K (~126.6 °C)
Flash Point 10 °C (closed cup)
Vapor Pressure @ 37.7 °C 4.1 kPa
Solubility 4.01 g/L water @ 20 °C
Refractive Index (n₂₀ᴅ) 1.414
Molecular Weight 129.24 g/mol (C₈H₁₉N)

Applications

  • Organic synthesis base: Ideal non-nucleophilic base for peptide coupling (e.g. via HATU/EDC), acylations, and deprotonations.
  • Catalyst & reagent : Used in Michael additions, Knoevenagel condensations, and polymerization.
  • Peptide synthesis :High steric hindrance minimizes side reactions in peptide coupling.
  • Lab solvent supplement : Neutralizes acid by-products in situ.

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