Protamine Sulfate

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CAS Number:9009‑65‑8

Synonyms: Protamine sulfate; Salmine sulfate

Chemical Formula:Complex mixture of ~5 kDa cationic peptides

Molecular Weight:~5,100 Da (major component)

Product Introduction

A white to off-white hygroscopic powder derived from salmon or synthetic sources. Protamine sulfate is a strongly basic, cationic polypeptide used clinically to neutralize heparin anticoagulation, and in biotech for viral transduction, DNA binding, and as a heparin antidote

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Physical & Chemical Properties

Property Value
Appearance White to off‑white powder
Solubility Sparingly soluble in water (~10 mg/mL)
Molecular Weight ≈ 5.1 kDa
Loss on Drying ≤ 5–10 %
Appearance (aqueous) Clear solution on warming

Applications

  • Heparin neutralization in clinical settings
  • Gene therapy & viral transduction enhancer
  • DNA/protein purification by precipitation
  • Antibacterial & enzymatic inhibition roles(e.g., pepsin)

Safety & Handling

  • Hygroscopic; avoid moisture. Use in ventilated area with PPE. Store tightly sealed at room temperature (<15 °C)

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