Diethyl Malonate

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DEMMe Chemical

CAS Number:609‑08‑5

Synonyms: Diethyl methyl malonate; Methylmalonic acid diethyl ester; Ethoxymalonate; DEMMe

Chemical Formula:C₈H₁₄O₄

Product Introduction

A colorless-to-pale liquid (or low-melt solid) ester with one methyl-substituted alpha carbon. It’s a versatile reagent for malonate chemistry—used in alkylations, Michael additions, and synthesis of erythromycin-like compounds and heterocycles.

Physical & Chemical Properties

Property Value
Appearance Colorless to pale-yellow liquid
Purity ≥ 98 % (GC)
Boiling Point ~199 °C
Flash Point ~82 °C
Specific Gravity @ 20 °C ~1.02
Refractive Index (n₂₀ᴅ) ~1.41
Molecular Weight 174.20 g/mol
Solubility Soluble in organics; slight water solubility

Applications

  • Malonate chemistry: Useful in Michael, alkylation, and Knoevenagel condensations for quaternary center formation.
  • Pharma/agrochemical syntheses: Employed in erythromycin analog manufacture and heterocycle building.
  • Research reagent: Valuable for complex molecule synthesis involving substituted malonates.
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