Diethyl ethoxymethylene malonate

Buy ethoxymethylene malonic acid diethyl ester in Mumbai, India

DEEM Chemical

CAS Number:831‑81‑8

Synonyms: Diethyl ethoxymethylene malonate; Ethoxymethylene malonic acid diethyl ester; DEEM

Chemical Formula:C₁₀H₁₆O₅

Product Introduction

DEEM is a pale‑yellow to colorless liquid or low‑melting solid, used as a versatile C‑1 synthon in Knoevenagel condensations, heterocycle synthesis, and for constructing quaternary centers. Frequently used in pharmaceutical and agrochemical multiplex syntheses.

Physical & Chemical Properties

Property Value
Appearance Colorless to pale‑yellow liquid or crystalline solid
Purity ≥ 98 % (GC)
Melting Point ~–20 °C (liquid range)
Boiling Point ~190 °C (decomposes)
Density ~1.04 g/cm³
Solubility Miscible with ethanol, ethers; slightly soluble in water
Molecular Weight 216.22 g/mol

Applications

  • C–C bond formation: Common in Knoevenagel condensations with aldehydes for alkene synthesis.
  • Heterocycle precursor: Building block for pyridones, pyridines, chromones, etc.
  • Pharma/agro syntheses: Useful in constructing quaternary centers via alkylation, Claisen, Michael, and acylation routes.
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