BETA-D-Ribofuranose 1,2,3,5-Tetraacetate

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Tetraacetate

CAS Number:13035‑61‑5

Synonyms: 1,2,3,5‑Tetra-O-acetyl-β-D-ribofuranose; β-D‑ribofuranose tetraacetate

Chemical Formula:C₁₃H₁₈O₉

Product Introduction

β-D-Ribofuranose 1,2,3,5‑tetraacetate is a white to off-white crystalline protected sugar derivative. The acetyl groups shield the ribofuranose hydroxyls, enhancing stability and solubility in organic solvents. It's a key intermediate in nucleoside and oligosaccharide synthesis and used in glycosylation mechanism studies.

Physical & Chemical Properties

Property Value
Appearance White to off-white crystalline powder
Purity ≥ 98 % (GC)
Melting Point 82–85 °C
Molecular Weight 318.28 g/mol
Density (est.) ~1.42 g/cm³
Solubility Soluble in ethyl acetate, chloroform; slight in water

Applications

  • Nucleoside synthesis:Serves as glycosyl donor for preparing pyrimidine and purine nucleoside analogues.
  • Mechanistic studies: Used in enzymatic assays to probe glycosyltransferase and glycosidase activity.
  • Protected carbohydrate: Intermediate in oligosaccharide assembly for research and pharmaceutical development.
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