Metalazone

Metalazone

CAS Number: 17560‑51‑9

Synonyms: Metolazone; Metalazone; SR‑720‑22; Zaroxolyn; Mykrox

Chemical Formula:C₁₆H₁₆ClN₃O₃S

Molecular Weight:365.83 g/mol

Product Introduction

Metolazone is a white crystalline diuretic (quinazoline class) used primarily to treat congestive heart failure and hypertension. It acts at the distal convoluted tubule to increase excretion of sodium, chloride, and water—offering potent edema relief

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Physical & Chemical Properties

Property Value
Appearance White to off‑white crystalline solid
Melting Point 252–254 °C
Boiling Point (predicted) ~613.6 °C
Density ~1.29 g/cm³
Refractive Index ~1.61 (estimated)
Solubility (DMSO) >5 mg/mL
Water Solubility ~60 mg/L @ 25 °C

Applications

  • Pharmaceutical:Diuretic for edema and hypertension
  • Analytical/Reference Standard: Used in drug testing, QC, and HPLC method validation

Safety

  • GHS category signals irritation to skin, eyes, and respiratory tract (H315, H319, H335) Use protective handling measures.

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