Imidazole

Imidazole

CAS Number:288‑32‑4

Chemical Formula:C₃H₄N₂

Product Introduction

A white to pale-yellow crystalline heterocycle, amphoteric (pKb≈7.0, pKa≈14.9), with aromatic character. Soluble in water and organics, used in pharmaceuticals, biochemical buffers (IMAC protein purification), epoxy curing, and coordination chemistry

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Physical & Chemical Properties

Property Value
Appearance White to pale-yellow solid (powder or flakes)
Melting Point 88–91 °C
Boiling Point ~256 °C
Density ~1.03 g/cm³ @ 20 °C
Vapor Pressure <1 mmHg @ 20 °C
Solubility ≈663 g/L in water; soluble in ethanol, ether
Refractive Index ~1.4655 n₂₀/D
pKa (in-water) ~6.95 at 25 °C
Log P ~0.02

Applications

  • Buffer in biochemical protocols (pH 6.2–7.8) and IMAC purification
  • Catalyst or curing agent in epoxy systems
  • Intermediate in pharmaceutical and agrochemical production
  • Coordination ligand in metal complexes

Safety & Handling

  • Irritant, mild toxicity; handle dust and vapors with PPE
  • Combustible at high temperature; sturdy packaging and good ventilation recommended

Packing Options

  • Lab: ≥99% purity, 25 g–1 kg glass bottles (AES, EP reference standards)
  • Industrial:25–100 kg drums or bulk packaging

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