Hydroxypiperidine

Hydroxypiperidine

CAS Number:5382‑16‑1

Synonyms:4‑Hydroxypiperidine; 4‑Piperidinol; C₅H₁₁NO

Chemical Formula:C₅H₁₁NO

Molecular Weight:101.15 g/mol

Product Introduction

A white to pale-yellow crystalline solid (≥98% purity). It is a hydroxylated piperidine used as an intermediate in pharmaceutical chemistry, including H₃ receptor antagonists, acridine derivatives, and as a building block in H‑ vs O‑arylation studies.

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Physical & Chemical Properties

Property Value
Appearance Off-white to pale‑yellow crystalline solid
Purity ≥98 % (GC, titration)
Melting Point 85–91 °C
Boiling Point ~114 °C at 10 mmHg
Density 0.99 g/cm³ (estimate)
Refractive Index (n₂₀ᴅ) ~1.44 (estimate)
Solubility Soluble in water; slight in methanol, chloroform
pH (aq soln) ~11.5–11.7

Applications

  • Pharma intermediates: Synthesis of H₃ receptor antagonists & acridine analogs.
  • Building block: Used in copper-catalyzed N- vs O-arylation chemistry.
  • Fine chemicals: Precursor in chemical research and reagent development.

Safety Notes:

  • Hazardous irritation properties (GHS H315, H319); mildly hygroscopic—store under inert atmosphere or desiccant.

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