Tri Methyl Ortho Acetate

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Tri Methyl Ortho Acetate

CAS Number:1445‑45‑0

Chemical Formula: C₅H₁₂O₃

Product Introduction

A colorless liquid (with faint fruity odor), moisture-sensitive orthoester. Acts as a reagent for protecting diols (acetal formation), esterification, and an intermediate in pharmaceuticals, pesticides, vitamins, and gas-phase organic syntheses

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Physical & Chemical Properties

Property Value
Appearance Colorless, clear to slightly yellow liquid
Melting Point ~–60 °C
Boiling Point ~107–109 °C
Density ~0.944 g/mL @ 20 °C
Vapor Pressure ~20–30 hPa @ 20 °C
Refractive Index ~1.388–1.392 @ 20 °C
Flash Point ~13–17 °C CC
Solubility Hydrolyzes in water; miscible in common organics
Log P ~1.13

Applications

  • Protects diols via acetal formation under acid catalysis.
  • Intermediate in synthesis of purine derivatives, vitamins B1/Vitamin A, formaldehyde scavenging, and fragrance compounds.
  • Used in esterification, acetal exchange chemistry, and in medicinal/agrochemical formulations

Safety & Handling

  • Danger:Flammable liquid & vapor (H225).
  • Skin and eye irritant (H317, H319).
  • Handle under dry conditions, protected from moisture and acids. Store sealed, cool (< 30 °C), in flame-proof area with grounding and ventilation.

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