Methane Sulfonyl Chloride

Methane Sulfonyl Chloride

CAS Number: 124‑63‑0

Synonyms: Methanesulfonyl chloride; Mesyl chloride; MsCl; Methanesulfonic acid chloride

Chemical Formula:CH₃SO₂Cl

Molecular Weight:114.55 g/mol

Product Introduction

A colorless to pale-yellow, moisture-sensitive, highly reactive organosulfur reagent. Commonly used to convert alcohols into mesylates, amines into sulfonamides, and generate transient sulfene for specialized syntheses.

Get Quote

Physical & Chemical Properties

Property Value
Appearance Colorless to pale-yellow liquid
Density @ 25 °C ~1.48 g/mL
Melting Point ~–32 °C
Boiling Point ~161 °C (@730 mmHg)
Solubility Reacts with water; soluble in alcohols, ethers, polar aprotics
Reactive Toward Water, alcohols, amines — exothermic reactions

Applications

  • Mesylate formation: for activating alcohols in substitution/elimination chemistry
  • Sulfonamide synthesis: from amines in pharma/agrochemical routes
  • Sulfene generation: for addition to alkynes/sultone formation
  • Other specialized reagents: beta‑chloro sulfones, acyliminium ion formation

Safety & Handling

  • Highly toxic, corrosive, lachrymator. Reacts violently with water/air. Store sealed under dry inert gas, refrigerated, in desiccator. Use full PPE, fume hood.

Products Category

+91 9867824846
Enquiry Now