1‑Bromo‑3‑Chloropropane

1‑Bromo‑3‑Chloropropane

CAS Number:109‑70‑6

Synonyms:3‑Bromopropyl chloride; Trimethylene chlorobromide; I‑BCP

Chemical Formula:C₃H₆BrCl

Product Introduction

A colorless, clear liquid used primarily as a C₃ linker/spacer in pharmaceuticals and organic synthesis. It's also leveraged as a phase-separation reagent in nucleic acid purification—a safer substitute for chloroform.

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Physical & Chemical Properties

Property Value
Appearance Colorless, clear liquid
Boiling Point 143–145 °C
Melting Point −59 °C
Density ~1.592 g/mL @ 25 °C
Vapor Pressure ~7.5 hPa (20 °C)
Refractive Index ~1.486 (n²⁰/D)
Flash Point ~81 °C

Applications

  • C₃-linker in API intermediates and medicinal chemistry
  • Phase-separation solvent for RNA isolation (chloroform alternative)

Safety & Handling:

  • Toxic via inhalation and dermal absorption (GHS: H302, H331)
  • Moderately flammable; use PPE, fume extraction, and store cool & sealed.

Safety & Handling:

  • 25 g–1 kg glass bottles (lab grade)
  • 200 L drums, IBCs (industrial)

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